Albert Science International Organization

ABSTRACT

Solid dispersion has attracted considerable interest as an efficient means of improving the dissolution rate and hence bioavailability of a range of hydrophobic drug. The present study was to enhance the solubility and dissolution rate of anti-HIV drug Nevirapine (NVP) by solvent evaporation method (SEM) and physical mixture method (PM) by using polymer such as HPMC E5 LV in different ratios like 1:1 to1:6. The solid dispersion in the solid-state was determined by solubility studies. The interaction of Nevirapine with HPMC E5LV was studied by using Fourier transform infrared spectroscopy (FTIR). Standard calibration curve and in vitro dissolution study of NVP was performed in HCl solution (pH 1.2). Based on the result the polymer HPMC E5 LV with ratio 1:4 and 1:3 by using the solvent evaporation method and physical mixture method respectively were selected for solid dispersion. The study shows that solubility of Nevirapine was successfully enhanced by using hydrophilic polymer such as HPMC E5LV which also increased the bioavailability of Nevirapine.

Keywords: Nevirapine, solid dispersion, HPMC E5LV, solubility, bioavailability.

1. J. Singh, M. Walia, S. L. Harikumar, “Solubility enhancement by solid dispersion method”, Journal of Drug Delivery & Therapeutics; 2013, 3(5), 148-155.
2. V. R. Tagalpallewar, M. A. Ughade, Dr. N. H. Indurwade, P. G. Kubare, A. A. Chintawar, “Enhancement of Solubility of a poorly water-soluble drug by solid dispersion technique”, International Journal of Pharma Sciences and Research (IJPSR), Vol. 6 No.2 Feb 2015, 352-361.
3. A. Datta, N. S. Ghosh, S. Ghosh, S. Tapobana And R. Chandra Das, “ Enhancement of solubility and dissolution profile of nevirapine by solid dispersion technique”, International journal of chemistry research, Vol 2, Issue 3, 2011, 53-58.
4. Mahmoud A. Younis,” Solid dispersion technology: A contemporary overview on well-established technique”, Universal Journal of pharmaceutical science and research, Volume 2, Issue 3, 2017, 15-19.
5. Abhire B. R., Rane B. R., Bakliwal S. R., Pawar S. P., “solubility enhancement of poorly water-soluble drug by solid dispersion technique”, International Journal of phaema tech research 2010, vol.2, no.3, 2007-2015.
6. K R Bobe, C R Subrahmanya, Sarasija Suresh, D T Gaikwad, M D Patil, T S Khade, B B Gavitre, V S Kulkarni and U T Gaikwad, “Formulation and evaluation of solid  dispersion of atorvastatin with various carriers”, pharmacy global international journal of comprehensive pharmacy,2011, vol.1(02), 1-6.