The novel corona virus disease has been rapidly spreading across the world, which made world health organization to declare it as pandemic. The name indicates because it has been never seen before and corona because it looks like the corona of sun. It’s basically a severe acute respiratory syndrome. A zoonotic disease originated in bats initially and then got transmitted to humans through unknown animals for the first time in wuhan, China. It is transmitted by inhalation or contact with infected droplets. The incubation period ranges from 2-14 days. The severity of disease may lead to pneumonia, acute respiratory distress syndrome and multi-organ dysfunction. The symptoms of disease are not very distinctive and include fever, cough, sore throat, breathlessness, fatigue, etc. Thus easy and early diagnosis of disease is difficult. Vulnerability of the disease perhaps seen in mostly elderly, infants and once with acute respiratory disease. Previously different corona viruses have emerged from time to time. The four corona viruses [HcoV-229E, Hco…] mainly associated with mild respiratory illness. Since these are zoonotic disease. They are mainly caused by the host bat. But the intermediate animals for SARS like corona virus are found to be masked palm civet cats and racoon dogs. The disease has become a fatal case in the world because no substantive treatment has yet been found to treat or prevent the disease Scientists all over the world are engaged in finding the solution to this pandemic. All they can do is rely on quarantine, isolation, infection control measures to prevent disease spread and on supportive care for those who become ill. But lack the specific antiviral agents to treat the infected and to optimally decrease viral spreading and subsequent transmission.
Keywords: Corona virus, COVID-19, MERS-CoV, SARS-CoV, Wuhan.
1] Wang C, Horbby PW, Hayden FG and Gao GF. A novel coronavirus outbreak of global health concern. Lancet. 2020. https://doi.org/10. 1016/S0140-6736(20)30185-9.
2] DD, Whitley RJ, Hayden FG. Clinical Virology, 4th ed. Washington: ASM Press; 2016. Coronavirus Outbreak. Available at: https://www.worldometers. info/coronavirus/. Accessed 23 Feb 2020.]
3] Chan-Yeung M, Xu RH. SARS: epidemiology. Respirology. 2003;8:S9–14.
4] Middle East Respiratory Syndrome Coronavirus. Available at: https://www.who.int/emergencies/mers-cov/en/. Accessed 16 Feb 2020.
5] World Health Organization. Situation reports. Available at: https:// www.who.int/emergencies/diseases/novel-coronavirus-2019/ situation-reports/. Accessed 22 Feb 2020.
6] H, Zhao Y, Zhang J, et al. Date of origin of the SARS coronavirus strains. BMC Infect Dis 2004;4:3.
7] Vega VB, Ruan Y, Liu J, et al. In 2003, the mutational dynamics of the SARS coronavirus in cell culture as well as human populations have been isolated. BMC Infect Dis 2004; 4:32.
8] Centers for Disease Control and Prevention (CDC). Update: Outbreak of severe acute respiratory syndrome--worldwide, 2003. MMWR Morb Mortal Wkly Rep. 2003;52(12):241–6.
9] World Health Organization. Coronavirus never before seen in humans is the cause of SARS– update 31. Geneva: The Organization; 2003.
10] World Health Organization. Situation reports. Available at:http://www.who.int/csr/sars/country/ta- ble2004_04_21/en/index.html. Accessed 14 feb 2020.
11] Peiris JS, Lai ST, Poon LL, Guan Y, Yam LY, Lim W, et al. Lancet. 2003;361:1319–25.
12] World Health Organization. WHO Statement Regarding Clus- ter of Pneumonia Cases in Wuhan, China Geneva 2020 [up- dated 9 January 2020 and 14 January 2020]. Available from: https://www.who.int/china/news/detail/09-01-2020-who- statement-regarding-cluster-of-pneumoniacases-in-wuhan- china.
13] Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Covid19 from Patients with Pneumonia in China, 2019. 24 January 2020. New England Journal of Medicine.
14] Mith I, Wang LF. Bats and their virome: an important source of originating viruses capable of infecting human beings. Curr Opin Virol 2013;3:84-91.
15] Balboni A, Battilani M, Prosperi S. fte SARS-like coronaviruses: the role of bats and evolutionary relationships with SARS coronavirus. New Microbiol 2012;35:1-16.
16] Ren W, Qu X, Li W, et al. Coolness in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin. J Virol 2008;82:1899-907.
17] Mailles A, Blanckaert K, Chaud P, van der Werf S, Lina B, Caro V, et al. First cases of Middle East respiratory syndrome Coro- navirus (MERS-CoV) infections in France, investigations and implications for the prevention of human-to-human trans- mission, Euro Surveill. 2013;18:20502.
18] Buchholz U, Müller MA, Nitsche A, Sanewski A, Wevering N, Bauer-Balci T, et al. Contact investigation of human’s case novel coronavirus infection treated in a German hospital, October-November 2012. Euro Surveill. 2013;18:20406.
19] Saif LJ. Animal coronaviruses: Rev Sci Tech. 2004;23:643–60.
20] Gwaltney JM Jr. Virology and immunology of the common cold. Rhinology. 1985;23:265.
21] Tyrrell DAJ, Myint SH. Chapter 60: Coronaviruses. In Barson 1 S, editor. Medical microbiology. 4th edition. Galveston: Univer- sity of Texas Medical Branch at Galveston; 1996.
22] World Health Organization. Situation reports. Available at: https:// www.who.int/emergencies/diseases/novel-coronavirus-2019/ situation-reports/. Accessed 22 Feb 2020.
23] Rothe C, Schunk M, Sothmann P, et al. N Engl J Med. 2020. https://doi.org/10.1056/NEJMc2001468.
24] Zou L, Ruan F, Huang M, et al. N Engl J Med. 2020. https://doi.org/10.1056/NEJMc2001737.
25] Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coronaviruses on insentient surfaces and its inactivation with biocidal agents. J Hosp Infect. 2020 Feb 6. pii: S0195–6701(20)30046–3.
26] De Souza Luna LK of Heisser V, Regamey N, Panning M, Drexler JF, Mulangu S, et al. J Clin Microbiol. 2007;45:1049–52.
27] Woo .PC, Lau SK, Huang Y, Yuen KY. Coronavirus diversity, phy- logeny and interspecies jumping. Exp Biol Med (Maywood). 2009;234:1117–27.
28] Letko M, Munster V. Functional valuation of cell entry and receptor usage for lineage B β-coronaviruses, including 2019.
29] Coronavirus Outbreak. Available at: https://www.worldometers. info/coronavirus/. Accessed 23 Feb 2020.
30] Chen N, Zhou M, Dong X, et al. Epidemiological and clinical features of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507–13.
31] WHO. Clinical management of SARS infection when novel coronavirus [nCoV] infection is suspected. Available at: https://www.who.int/publications-detail/clinical-management- of-severe-acute-respiratory-infection-when-novelcoronavirus-[ncov]-infection-is suspected. Accessed 9 Feb 2020.