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JOURNALS || ASIO Journal of Pharmaceutical & Herbal Medicines Research (ASIO-JPHMR) [ISSN: 2455-281X]
MICRO-EMULSION: AN OVERVIEW

Author Names : Preeti Kamaria
Page No. : 05-16
Read Hit : 859
Pdf Downloads Hit : 9  volume 1 issue 1
Article Overview

ARTICLE DESCRIPTION: 

Preeti Kamaria, Anamika Saxena, Ayushi patwa, Ashok Dashora. Micro-Emulsion: An Overview, ASIO Journal of Pharmaceutical & Herbal Medicines Research (ASIO-JPHMR), 2015, 1(1): 05-16.

ARTICLE TYPE: REVIEW

dids/doi No.: 12.2015-77737978

dids link: http://dids.info/didslink/12.2015-77128968/ 

ABSTRACT:

Micro-emulsions are isotropic, thermodynamically stable transparent (or translucent) systems of oil, water and surfactant, frequently in combination with a co-surfactant with a droplet size usually in the range of 20-200 nm. They can be classified as oil-in-water (o/w), water-in-oil (w/o) or bi-continuous systems depending on their structure and are characterized by ultra low interfacial tension between oil and water phases. These adaptable delivery systems provide protection against oxidation, enzymatic hydrolysis and improve the solubilization of lipophilic drugs and hence enhance their bioavailability. Micro-emulsion formulated with suitable excipients may also prove to be suitable vehicles for delivery of labile (peptide) and poorly soluble drugs. Micro-emulsions have higher solubilising capacities than simple micellar solution and their thermodynamic stability  offers advantages over unstable dispersions, such as emulsions, suspensions because they can be manufactured with little energy input and have a long shelf life, the enormous interfacial areas associated with  micro-emulsions would influence the transport properties of drug, an important factor in targeted and sustained drug delivery through ophthalmic, dental, pulmonary, vaginal and topical routes.

KEYWORDS: Micro-emulsion, Thermodynamic stability, co-surfactant, phase behavior study, Targeted delivery

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