Albert Science International Organization

ARTICLE DESCRIPTION: 

Shagufta Farooqui, Vijayalaxmi Narayan Jogadand, Dipak Bhagvat Gaikwad,  Rushikesh Prakash Gavali, Sudarshan Bhaurao Raut, A review on bilayer tablets, ASIO Journal of Drug Delivery, 2020, 4(1): 16-20.

ARTICLE TYPE: REVIEW

DOI Link:: 10.2016-21915953/ ;

DOI Link :: http://doi-ds.org/doilink/07.2020-48995273/

ABSTRACT:

Bilayer tablet is new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Controlled release dosage forms have been extensively used to improve therapy with several important drugs. Use of bilayer tablet is a very different aspect for anti-inflammatory and analgesic. Bi-layer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one Layer is immediate release as initial dose and second layer is maintenance dose. Bilayer tablet is improved beneficial technology to overcome the shortcoming of the single layered tablet. In the case of bilayered tablets drug release can be rendered almost unidirectional if the drug can be incorporated in the upper nonadhesive layer its delivery occurs into the whole oral cavity.

KEYWORDS: Bilayer tablet, GMP requirement for bi-layer tablets, various tablet presses, RoTotab push technology and DUROS technology.

[1] Jayprakash S, Mohamed HS, Kulathuran PK, Vignesh N, Mohamed Firthhouse PU, Boopathi M, Formulation And Evaluation of Bilayer Tablets of Metformin Hydrochloride, Asian Journal of Pharmaceutical And Health Science, 2011,1(4):183-188.

[2] Divya A, Kavitha K, Kumar MR, Dakshayani S, Jagadees Singh SD, Bilayer Tablet Technology: An Overview, Journal of Applied Pharmaceutical Science, 2011, 01 (08): 43-47.

[3] Buri P, Puisicux F, Doelker E, Benoit J P. Formes Pharma centiques Nouvelles, Ed. Technique et Documentation, Lavoisier, Paris, 1985.

[4] Lee L. Diffusion-controlled matrix systems, in: A. Kydonieus (Ed.), Treatise on Controlled Drug Delivery, Marcel Dekker, New York, 1992, 4: 155- 198.

 [5] Deshpande R, Govda DV, Bilayer Tablets an Emerging Trends: A Review, International Journal of Pharmaceutical Sciences and Research, 2011, 2(10): 2534-2544.

[6] Panchal HA, Tiwari AK, A Novel Approach of Bilayer Tablet Technology: A Review, International Research Journal of Pharmacy, 2012, 3 (5): 44-49.

[7] Shila V. Devtalu Ashwini E. Patil, Manoj M. Bari, Dr. Shashikant D. Barhate, A Review on Novel Approach – Bilayer Tablet Technology International Journal of Pharmaceutical Sciences Review and Research  Jul – Aug 2013;  21(1):46-52.

[8] Peppas N A, Boca Raton F L. Hydrogels in Medicine and Pharmacy, CRC Press, 1988, 1(2):65.

[9] Meraj Sultana Syed, M. Venkata Anjaneyulu, Chejeti Anusha1, Vijaya Shekar Reddy Chejeti1, a review article on bilayer tablets International Journal of Research in Pharmaceutical and Nano Sciences. 2013, 2(4): 417 - 422.

[10] Panchal HA, Tiwari AK, A Novel Approach of Bilayer Tablet Technology: A Review, International Research Journal of Pharmacy, 2012, 3 (5): 44-49.

[11] Pujara ND, Gokani RK, Paun JS, Bilayer Tablet: An Emerging Trend, International Journal of Pharmaceutical Research and Development, 2012, 4(04): 101-112.

[12] Muzzio, F.J., Lerapetritou, M., Portillo, P., Llusa, M., Levin, M., Morris, K.R., Soh. P.J., McCann, R. J., Alexander, A. A forward-looking approach to process scale-up for solid dose manufacturing. In: Augsburger, L.L., Hoag, S.W. (Eds.), Pharmaceutical Dosage Forms: Tablets, 2008.  Volume 3:

[13] Martin A, Bustamante P and Chun A. Micromeritics in Physical Pharmacy-Physical Chemical Principles in the Pharmaceutical Sciences, Lippincott Williams and Wilkins, Baltimore, 2002, 4: 446-448.

[14] Nilawar M P S. An Emerging Trend on Bilayer Tablets, International Journal of Pharmacy and Pharmaceutical Science Research, 2013, 3(1): 15-21.