Albert Science International Organization

ARTICLE TYPE: RESEARCH [WITHDRAWN AND DELETED FULL MANUSCRIPT DUE TO SOME COPY RIGHT ISSUE]

ARTICLE REFERANCE ID.: ASIO-JDD: 2020/914

ABSTRACT:

The intention behind the present work was to develop a microsphere based novel dosage form for sustained delivery of Omeprazole. Omeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By directly acting on the proton pump, omeprazole blocks the final step in acid formation, thus reducing the gastric acid. The microsphere framework is based on the idea that its structure will encroach on the substance inside it. Comparative study was conducted using Eudragit RS 100 and Ethyl cellulose with different drug-polymer ratios for the preparation of microspheres. Several factors that affect the physical properties of the microsphere have been investigated for optimisation purposes. It was employed to systematically optimize the drug release profile, encapsulation efficiency & drug content. The characterization techniques followed for the microspheres developed were an study of FTIR, SEM, XRD and particle size along with drug content, development yield, encapsulation efficiency and drug release in vitro. The studies of in vitro dissolution were done to evaluate the drug's release pattern from the microspheres over a period of twelve hours. The omeprazole release was sustained by microspheres up to 12 hrs. From the FTIR study it is found that by both the methods Process parameters does not make any structural changes in Omeprazole. XRD study showed that sharp peaks for the pure drug  Hence, known to possess same internal structure. The research on SEM was conducted to determine the morphology and surface topography of prepared microspheres. In this study, Microspheres of Omeprazole were successfully prepared using the Spray Drying Method and the Emulsion Solvent Evaporation Method.

KEYWORDS: Microsphere, Emulsion Solvent Evaporation Method, Spray Drying, Omeprazole, Sustained Delivery, Optimization.

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