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JOURNALS || ASIO Journal of Experimental Pharmacology & Clinical Research (ASIO-JEPCR) [ISSN: 2455-7080]

Author Names : Amit Gupta
Page No. : 41-53  Volume 6 Issue 1
Article Overview


Amit Gupta, Metal induced testicular toxicity, ASIO Journal of Experimental Pharmacology & Clinical Research (ASIO-JEPCR), 2020, 6(1): 41-53.


Affiliation: Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, U.P., India.

Doi: 10.2016-37245516/;

DOI Link ::


Metal exposure leads to severe damage in male reproductive organs affecting male fertility. Although many of the metals are essential for various biological processes but on the other hand, these essential metals become toxic with the increasing dose and exposure. The primary objective of this review article is to find out the various metal induced toxicity on the reproductive system of male, especially on testicular system. The main aim is to collect the all data in a cumulative way and to compile all of these and represent them in a tabulated form. The overall result of this review offer a confirmation that certain transition metals such as As, Cd, Cr, Hg, Mn, Mo, Pb, Ni, V and Zn may adversely affect male reproductive functions such as spermatogenesis, sperm quality, secretory functions of accessory glands, libido, fertility, serum testosterone level and antioxidant defense system. Most of the reports on the reproductive toxicity of transition metals are from experimental animal studies.

Keywords: Metal toxicity, reproductive system, testicular toxicity, spermatogenesis.

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