Albert Science International Organization

ARTICLE DESCRIPTION: 

Deshmukh Shachi, S. K. Sarje, N. B. Ghiware, Phytochemical and pharmacological evaluation of terminalia catappa linn. leaves extracts for antiamnetic activity, ASIO Journal of Experimental Pharmacology & Clinical Research (ASIO-JEPCR), 2020, 6(1): 69-78.

ARTICLE TYPE: RESEARCH

Affiliation: Department of Pharmacology, Nanded Pharmacy College, Nanded, Maharashtra, India. 

Doi: 10.2016-37245516/;

DOI Link:: http://doi-ds.org/doilink/08.2020-69978618/

ABSTRACT:

The present study reports physicochemical characterization, antioxidant and Antiamnetic activity of extracts from Tarminalia catappa leaves collected from local region of Nanded, Maharashtra, India. Different physical parameters like ash values, extractive value, Loss on drying, solubility etc were evaluated for powdered drug. The extracts were obtained from Soxhlet method by using water and methanol as solvents for extraction and subjected for preliminary physicochemical evaluation and antioxidant studies. Total phenolic and flavonoids content were also analyzed. The presence of primary and secondary metabolites such as carbohydrate, proteins, alkaloids, phenolic compounds, saponins was confirmed through preliminary phyto-chemical analysis. DPPH free radical scavenging assays showed strong antioxidant activities with increase in concentration of acetone and methanol leaf extracts. The In-Vivo antiamnetic activity of Terminalia catappa leaf was evaluated by radial arm maze model in rats using Piracetam as a standard. Scopalaminre (1mg/kg) used as indusing agent. Both the extracts at 200mg/kg concn showed significant to highly significant number of entries & time spent in P zone (from P < 0.05 to P < 0.001).

Keywords: Terminalia catappa, Acetone and Methanolic extract, Phytochemical screening, Antioxidant effect, antiamnetic activity.  

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