Deshmukh Shachi, S. K. Sarje, N. B. Ghiware, Phytochemical and pharmacological evaluation of terminalia catappa linn. leaves extracts for antiamnetic activity, ASIO Journal of Experimental Pharmacology & Clinical Research (ASIO-JEPCR), 2020, 6(1): 69-78.
ARTICLE TYPE: RESEARCH
Affiliation: Department of Pharmacology, Nanded Pharmacy College, Nanded, Maharashtra, India.
DOI Link:: http://doi-ds.org/doilink/08.2020-69978618/
The present study reports physicochemical characterization, antioxidant and Antiamnetic activity of extracts from Tarminalia catappa leaves collected from local region of Nanded, Maharashtra, India. Different physical parameters like ash values, extractive value, Loss on drying, solubility etc were evaluated for powdered drug. The extracts were obtained from Soxhlet method by using water and methanol as solvents for extraction and subjected for preliminary physicochemical evaluation and antioxidant studies. Total phenolic and flavonoids content were also analyzed. The presence of primary and secondary metabolites such as carbohydrate, proteins, alkaloids, phenolic compounds, saponins was confirmed through preliminary phyto-chemical analysis. DPPH free radical scavenging assays showed strong antioxidant activities with increase in concentration of acetone and methanol leaf extracts. The In-Vivo antiamnetic activity of Terminalia catappa leaf was evaluated by radial arm maze model in rats using Piracetam as a standard. Scopalaminre (1mg/kg) used as indusing agent. Both the extracts at 200mg/kg concn showed significant to highly significant number of entries & time spent in P zone (from P < 0.05 to P < 0.001).
Keywords: Terminalia catappa, Acetone and Methanolic extract, Phytochemical screening, Antioxidant effect, antiamnetic activity.
. Joshi H., Parle M; Evaluation of the antiamnesic effects of Phyllanthus amarus in mice. Colomb Med; 2007: 3, 132-139.
. D.S. Mohale, A.P. Dewani, A.V. Chandewar, C.D.Khadse, A.S. Tripathi1, S.S. Agrawal, Brief Review On Medicinal Potential Of Terminalia Catappa Journal of Herbal Medicine and Toxicology ,2009: 3 (1), 7-11.
. Khandelwal K. R. Practical Pharmacognosy NiraliPrakashan, 21th edition, 2010: 25.1-25.9
. Biju J, Sulajman CT, Satheesh G, Reddy VR. Total Phenolics and Flavonoids in Selected Medicinal Plants from Kerala. Int J of Phar and Pharm Sci., 2014: 6(1), 406-408.
. US, Muhammad MA, Azwani MS, Nasyriq A. Determination of Total Phenolics, Flavonoids Content and Free Radical Scavenging Activities of Common Herbs and Spices. J of Pharmacognosy and Phytochemistry, 2014: 3(3), 104-108.
. Dildar A, Muhammad MK, Ramsha S. Comparative Analysis of Phenolics, Flavonoids, Antioxidant and Antibacterial Potential of Methanolic, Hexanic and Aqueous Extracts from Adiantum Caudatum Leaves. Antioxidants, 2015: 4, 394-409.
. Shaik GP, Shaik KS, Shaik YA, Imaduddin, Roshan S, Saffon AK. Evaluation of Antiepileptic and Antioxidant Activity of Methanolic Extract of Terminalia Tomentosa (Roxb) Wight and Arn in Rats. World J of Pharm Res., 2015: 4(2), 766-776.
. H. Gerhard Vogel, Drug discovery & evaluation, Pharmacological assays, II edition, 2002: 936-944.
. Shahina Naz, Samia Ahmad, Sheikh Ajaz Rasool, Rahmanullah Siddiqi and Syed Asad Sayeed, : Res J Microbiol, 2007: 2, 180-184.
. Gilman, E.F., Watson, D.G., Terminalia catappa. Tropical- Almond, Fact Sheet ST 1994: 3, 626-629.