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JOURNALS || ASIO Journal of Experimental Pharmacology & Clinical Research (ASIO-JEPCR) [ISSN: 2455-7080]
PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF TERMINALIA CATAPPA LEAVES EXTRACTS FOR ANTIDEPRESSANT ACTIVITY

Author Names : Aarti Muttewar
Page No. : 92-101  Volume 6 Issue 1
Article Overview

ARTICLE DESCRIPTION: 

Aarti Muttewar, N. B Ghiware, S. K. Sarje, Shaikh Arshad, Phytochemical and pharmacological evaluation of terminalia catappa leaves extracts for antidepressant activity, ASIO Journal of Experimental Pharmacology & Clinical Research (ASIO-JEPCR), 2020, 6(1): 92-101.

ARTICLE TYPE: RESEARCH

Affiliation: Department of Pharmacology, Nanded Pharmacy College, Nanded, Maharashtra, India. 

Doi: 10.2016-37245516/;

DOI Link :: http://doi-ds.org/doilink/08.2020-34175523/


ABSTRACT:

The present study reports physicochemical characterization, antidepressant activity of extracts from Terminalia Catappa leaves collected from local region of Nanded, Maharashtra, India. Different physical parameters like ash values, extractive value, Loss on drying, solubility etc were evaluated for powdered drug. The extracts were obtained from Soxhlet method by using water and methanol as solvents for extraction and subjected for preliminary physicochemical evaluation and antioxidant studies. Total phenolic and flavonoids content were also analyzed. In-vivo Antidepressant effect of Terminalia Catappa Linn. Leaves was determined by Despair Swim test method using Imipramine (15mg/kg orally) as standard were two extracts as 200mg/kg Concentration showed significant to highly significant result of decrease in time of immobility on 8th and 15th day of experiment.

Keywords: Terminalia Catappa Linn., Acetone and methanol extract, Phytochemical screening, Antioxidant effect, Antidepressant activity, Despair Swim test.

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