Albert Science International Organization

ARTICLE DESCRIPTION: 

Aarti Muttewar, N. B Ghiware, S. K. Sarje, Shaikh Arshad, Phytochemical and pharmacological evaluation of terminalia catappa leaves extracts for antidepressant activity, ASIO Journal of Experimental Pharmacology & Clinical Research (ASIO-JEPCR), 2020, 6(1): 92-101.

ARTICLE TYPE: RESEARCH

Affiliation: Department of Pharmacology, Nanded Pharmacy College, Nanded, Maharashtra, India. 

Doi: 10.2016-37245516/;

DOI Link :: http://doi-ds.org/doilink/08.2020-34175523/

ABSTRACT:

The present study reports physicochemical characterization, antidepressant activity of extracts from Terminalia Catappa leaves collected from local region of Nanded, Maharashtra, India. Different physical parameters like ash values, extractive value, Loss on drying, solubility etc were evaluated for powdered drug. The extracts were obtained from Soxhlet method by using water and methanol as solvents for extraction and subjected for preliminary physicochemical evaluation and antioxidant studies. Total phenolic and flavonoids content were also analyzed. In-vivo Antidepressant effect of Terminalia Catappa Linn. Leaves was determined by Despair Swim test method using Imipramine (15mg/kg orally) as standard were two extracts as 200mg/kg Concentration showed significant to highly significant result of decrease in time of immobility on 8^th and 15^th day of experiment.

Keywords: Terminalia Catappa Linn., Acetone and methanol extract, Phytochemical screening, Antioxidant effect, Antidepressant activity, Despair Swim test.

[1]. Depression Guideline Panel. Depression in Primary Care: Volume 1. Detection and Diagnosis Clinical Practice Guideline, Number 5. Rockville, Maryland: U.S Department of Health and Human Services, 2001: 3 (1), 93-0550.

[2]. D. S. Mohale, A .P. Dewani, A. V. Chandewar, C. D. Khadse, A.S. Tripathi, S. S. Agrawal, Brief Review On Medicinal Potential of Terminalia Catappa Journal of Herbal Medicine and Toxicology ,2009: 3 (1), 7-11.

[3]. Khandelwal K. R. Practical Pharmacognosy NiraliPrakashan, 21^th edition, 2010: 25.1-25.9.

[4]. Biju J, Sulajman CT, Satheesh G, Reddy VR. Total Phenolics and Flavonoids in Selected Medicinal Plants from Kerala. Int J of Phar and Pharm Sci 2014: 6(1): 406-408.

[5]. US, Muhammad MA, Azwani MS, Nasyriq A. Determination of Total Phenolics, Flavonoids Content and Free Radical Scavenging Activities of Common Herbs and Spices. J of Pharmacognosy and Phytochemistry, 2014: 3(3): 104-108.

[6]. Dildar A, Muhammad MK, Ramsha S. Comparative Analysis of Phenolics, Flavonoids, Antioxidant and Antibacterial Potential of Methanolic, Hexanic and Aqueous Extracts from Adiantum Caudatum Leaves. Antioxidants, 2015; 4: 394-409.

[7]. Shaik GP, Shaik KS, Shaik YA, Imaduddin, Roshan S, Saffon AK. Evaluation of Antiepileptic and Antioxidant Activity of Methanolic Extract of Terminalia Tomentosa (Roxb) wight and Arn in Rats. World J of Pharm Res., 2015; 4(2): 766-776.

[8]. H. Gerhard Vogel, Drug discovery & evaluation, Pharmacological assays, II edition, 2002; 936-944.

[9]. Shahina Naz, Samia Ahmad, Sheikh Ajaz Rasool, Rahmanullah Siddiqi and Syed Asad Sayeed, :Res J Microbiol, 2007: 2, 180-184.

[10]. Gilman, E. F., Watson, D. G, Terminalia catappa. Tropical- Almond” Fact Sheet ST 1994: 3, 626-629.

[11]. Deshmukh Shachi, S. K. Sarje, N. B. Ghiware, Phytochemical and pharmacological evaluation of terminalia catappa linn. leaves extracts for antiamnetic activity, ASIO Journal of Experimental Pharmacology & Clinical Research (ASIO-JEPCR), 2020, 6(1): 69-78.

[12]. Kharate Pooja, N. B. Ghiware, S. K. Sarje, Phytochemical and pharmacological evaluation of terminalia catappa linn. leaves extracts for antianxiety activity, ASIO Journal of Experimental Pharmacology & Clinical Research (ASIO-JEPCR), 2020, 6(1): 79-91.