Thakur Adhika Govindsinh, M. H. Ghante, N. B. Ghiware, S. K. Sarje, Pharmacological evaluation of ruellia tuberosa stem bark on antianxiety activity, ASIO Journal of Experimental Pharmacology & Clinical Research (ASIO-JEPCR), 2020, 6(1): 102-108.
ARTICLE TYPE: RESEARCH
Affiliation: Department of Pharmacology, Nanded Pharmacy College, Nanded, Maharashtra, India.
DOI Link :: http://doi-ds.org/doilink/08.2020-74671641/
Anxiety is one of the most common mental disorders, which affects more than 10-15% of the population. It is a psychological and physiological state characterised by somatic, emotional, cognitive and behavioural components associated with significant disability which has a negative impact on the quality of life. The objective of the study was to investigate the antianxiety activity of Methanolic and Ethyl acetate extracts of Ruellia tuberosa stem bark. The stem bark of Ruellia tuberosa belongs to the family Acanthaceae and used as diuretic, anti diabetic, antipyretic, analgesic, antihypertensive, gastro protective, used to treat gonorrhoea, thirst quenching, antinociceptive and anti-inflammatory. The potential antianxiety activity of Ruellia tuberosa was studied in Wistar albino rats. The evaluation of in-vitro antianxiety activity in rats was done using various experimental models Elevated plus Maze test and Light and dark test. The extract administered orally in two doses (200mg/kg and 100mg/kg p.o.) during a 5min period for elevated plus maze test and 10 min for light and dark test evaluation parameters were recorded. Diazepam 2mg/kg i.p. was used as a standard drug. Evaluation of Elevated plus includes No. of entries in open and closed arm, time spent in open and closed arm and time spent in central zone whereas Light and dark test evaluates time spent in light and dark zone, No. of entries in light and dark zone. The Methanolic test rats showed the increased locomotor activity and behavioural changes at a concentration of 200mg/kg and 100mg/kg as compared to ethyl acetate.
Keywords: Ruellia tuberosa stem bark, Antianxiety activity, Elevated plus maze test, Light and dark test, Methanol, Ethyl acetate.
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