Albert Science International Organization

ARTICLE DESCRIPTION: 

Dudutari E. Patani, Godwin P. Angaye, and Iniobaong R. Inyang, The xenobiotic effect of 2, 4-dimethylamine salt (720 g/l) on electrolytes and metabolites in new zealand rabbits (Oryclotagus Cuniculus), Journal of Medical & Health Sciences Research (ASIO-JMHSR), 2020, 4(2): 27-33.

^1,2Department of Biology, Bayelsa Medical University, Yenagoa, Bayelsa State, Nigeria.

3Department of Biological Sciences, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria.

doi: 10.2016-74831794;

DOI Link :: http://doi-ds.org/doilink/12.2020-67286456/

ABSTRACT:

Pesticides are generally toxic and exert serious biocidal effects on target and nontarget organisms. To ascertain this fact, thirty (30) adult New Zealand Rabbits (Oryclotagus Cuniculus) whose weight average 2.0kg were used for the toxicity bioassay of Aminoforce containing 720 g/l 2, 4-Dimethylamine salt. The test animals where orally administered with three concentrations (2.00 ppm, 4.00 ppm and 6.00 ppm) of toxicant for 21 days. The muscle from each exposed animal were collected, crushed and homogenized with deionized water for electrolyte assessment. Also, blood samples were collected and centrifuged for 15 minutes at 3000 rpm. Results of this study confirmed a decline in blood metabolites like; total protein, albumin, bilirubin and creatinine, while urea value appreciated. Measured electrolytes in the muscle such as sodium (Na⁺) appreciated while potassium (K⁺) declined. But that of Magnesium and Chloride ion values in the muscle stabilized in the experimental group, thus being not significantly different (p>0.05) across the various concentrations of the toxicants. This result confirmed the toxicity of the toxicant on metabolic and electrolyte parameters of exposed animals. Thus 2, 4-dimethylamine salt should be handled and used cautiously in order to avoid its toxicity.

Key Words: Aminoforce, Herbicide, Metabolites, Electrolytes.

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