Albert Science International Organization

ARTICLE DESCRIPTION: 

Affiliation:

¹Kushal Nandi, ¹Shayari Dutta, ¹Dr. Bankim Chandra Nandy, ¹Dr. Beduin Mahanti, ¹Dr. Falguni Patra, ¹Dr. Khokan Bera, ¹Dr. Dhrubo Jyoti Sen*, ²Dr. Dhananjoy Saha and ³Antarip Mahanti

¹ Department of Pharmaceutical Chemistry & Pharmaceutics, School of Pharmacy, Techno India University, Salt Lake City, Sector V, EM-4, Kolkata-700091, West Bengal, India.

² Deputy Director, Directorate of Technical Education, Bikash Bhavan, Salt Lake City, Kolkata-700091, West Bengal, India.

³ Indian Institute of Science Education and Research, Kolkata, Mohanpur, Nadia-741246, West Bengal, India.

ARTICLE TYPE: REVIEW

DOI : 10.2016-19146535/ ; 

DOI Link :: http://doi-ds.org/doilink/02.2021-31939378/ASIO-JPHMR/v1/i1/2021/453

Abstract:

In the new era, interest in developing a combination of two or more Active Pharmaceutical Ingredients (API) in a single dosage form (bilayer tablet) has increased in the pharmaceutical industry, for promoting patient convenience and compliance.  A bilayer tablet involves the compression of two formulations into a single solid oral tablet, while maintaining a physical separation of the formulations by layering on top of the other. Bilayer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one Layer is immediate release as initial dose and second layer is maintenance dose. This article provides an overview of the bilayer tablet technology, highlighting the main benefits of this type of oral dosage forms while providing a description of current challenges and advances toward improving manufacturing practices and product quality. This article also provides an overview of different approaches and technologies introduced in bilayer tablet.

Keywords: Active Pharmaceutical Ingredients (API), bilayer tablet, sustained release, immediate release

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