Albert Science International Organization

ARTICLE DESCRIPTION: 

Shibam Acharya, Souvik Mallik, Soumya Rakshit, Sabuj Kumar Bhattacharya, Partha Sarathi Mondal, Sanjoy De,  Bankim Chandra Nandy, An overview of nebulized drug delivery system and their application in different fields, ASIO Journal of Drug Delivery, 2021, 5(1): 01-11.

ARTICLE TYPE: REVIEW

DOI Link:: http://doi-ds.org/doilink/10.2016-21915953/ ;

DOI Link :: http://doi-ds.org/doilink/06.2021-54799599/ASIO-JDD: 2021/919

ABSTRACT:

Different technological advancements and developments have been performed worldwide in the avenue of inhalation therapy. Nebulization is a common method for generating medical aerosol and is used worldwide by adults and children. Nebulizer is a electrically powered or battery powered machine that turn liquid medication into a mist so that it can be breathed directly into the lungs. Nebulized Pharmacological therapy is used treatments for patients with asthma and COPD. People suffered from COPD died every year in low- and middle-income countries. Current guidelines emphasized on inhaled pharmacology therapy as the favorable route of administration for treating COPD, asthma and various other pulmonological diseases. A successful pulmonary administration requires a harmonic interaction between the drug formulation, the inhaler device, and the patient. This review describes the various features of nebulizer delivery devices concerning mechanisms of aerosol generation, their use with different formulations, and their advantages and disadvantages.

Keywords: Technological advancement, Inhalation therapy, Aerosol generation, pulmonary problems, COPD, Mist generation.

1. https://en.wikipedia.org/wiki/Nebulizer
2.  Medical Dictionary. "Nebulizer". Retrieved 2010-11-01.
3.  Boe J, Dennis JH, O'Driscoll BR, et al. (July 2001). "European Respiratory Society Guidelines on the use of nebulizers". Eur. Respir. J. 18 (1): 228-42. doi:10.1183/09031936.01.00220001. 
4.  Finlay, W.H. (2001). The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction. Academic Press.
5. Denyer J, et al. (2000). "New liquid drug aerosol devices for inhalation therapy". Eur Respir Rev. 10: 187–191.
6. NEBULIZATION Presented By:Ms. Sinsu Rachel Alex MSc. https://www.slideshare.net/sinsu12/nebulization-105157952
7. https://images.app.goo.gl/JGu6z5dtaytfPsPu8
8. https://images.app.goo.gl/Pvb3VCrs8pXbWLjB8
9. https://images.app.goo.gl/hA99eYB7JkteC7Vi7
10. S. Prajapati, S. Saha, C. D. Kumar and B. Sahoo, Nebulized drug delivery: an overview, Article Information Sr no: 8, Page no: 3575-3582, DOI: 10.13040/IJPSR.0975-8232.10(8).3575-82.
11. https://aeroflowinc.com/how-do-nebulizers-work/
12. Santosh Thorat , International Journal of Pharmaceutical Science and Volume 1; Issue 5; July 2016; Page No. 30-35.
13.   https://www.webmd.com/asthma/guide/home-nebulizer-therapy
14. https://www.wikihow.com/Clean-a-Nebulizer
15. Donald P Tashkin, Int J Chron Obstruct Pulmon Dis. 2016; 11: 2585–2596.Published online 2016 Oct 18. doi: 10.2147/COPD.S114034,PMCID: PMC5076803,PMID:27799757 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076803/
16. Michael j. welch, MD,FAAP, FAAAI, Sage journal,clinical pediatrics,volume 47 Number 8 October 2008 744-756 .
17. Pieter R Tuinman, Barry Dixon, Marcel Levi, Nicole P Juffermans, and Marcus J Schultz, Crit Care. 2012; 16(2): R70. Published online 2012 Apr 30. doi: 10.1186/cc11325,PMCID: PMC3681399,PMID: 22546487 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681399/
18. Shan Lyu, Jie Li, Limin Yang, Xiaoliang Du, Xiaoyi Liu, Libo Chuan, Guoqiang Jing, Zhenyan Wang, Weiwei Shu, Chunjuan Ye, Qionglan Dong, Jun Duan, James B. Fink, Zhancheng Gao, Zongan Liang; on behalf of Respiratory Care Committee in Chinese Thoracic Society, The utilization of aerosol therapy in mechanical ventilation patients: a prospective multicenter observational cohort study and a review of the current evidence. Submitted Feb 04, 2020. Accepted for publication Jul 24, 2020. doi: 10.21037/atm-20-1313. https://atm.amegroups.com/article/view/51354/html
19. Nebulizers for Babies: How They Help Treat Respiratory Issues Medically reviewed by Melanie Santos — Written by Rachel Nall, MSN, CRNA on September 26, 2018.  https://www.healthline.com/health/nebulizer-for-baby#guide
20. Centers for Disease Control and Prevention. Coronavirus Disease 2019 (COVID-19) Healthcare Infection Prevention and Control FAQs for COVID-19; Updated April 23, 2020. Available from: https://www.cdc.gov/coronavirus/2019-ncov/hcp/infection-control-faq.html. [Last accessed on 2020 Apr 30].
21. Home nebulizer therapy Medically reviewed by J. Keith Fisher, M.D. — Written by Danielle Dresden on June 28, 2019  https://www.medicalnewstoday.com/articles/325607#what-is-it
22. https://pubmed.ncbi.nlm.nih.gov/32397615/#:~:text=Aerosol%20therapy%20is%20a%20key,and%20minimizing%20systemic%20side%20effects
23. L. Máiz, C. Wagner. Beneficios de la terapia nebulizada: conceptos básicos. Arch Bronconeumol, 47 (2011), pp. 2-7, http://dx.doi.org/10.1016/S0300-2896(11)70028-X.
24. J. Boe, J.H. Dennis, B.R. O’Driscoll, T.T. Bauer, M. Carone, B. Dautzenberg, European Respiratory Society Guidelines Task Force on the use of nebulizers, et al. European Respiratory Society Guidelines on the use of nebulizers. Eur Respir J, 18 (2001), pp. 228-242.
25. M. Dolovich, R. Ahrens, D. Hess, P. Anderson, R. Dhand, J.L. Rau, et al. Device selection and outcomes of aerosol therapy: evidence-based guidelines. Chest, 127 (2005), pp. 335-371, http://dx.doi.org/10.1378/chest.127.1.335.
26.  M.B. Dolovich, R. Dhand. Aerosol drug delivery: developments in design and clinical use. Lancet, 377 (2011), pp. 1032-1045. http://dx.doi.org/10.1016/S0140-6736(10)60926-9.
27. J.C. Waldrep, R. Dhand. Advanced nebulizer designs employing vibrating mesh/aperture plate technologies for aerosol generation. Curr Drug Deliv, 5 (2008), pp. 114-119.
28. F.S. Ram, D.M. Brocklebank, J. White, J.P. Wright, P. Jones. Pressurised metered dose inhalers versus all other hand-held inhaler devices to deliver beta2-agonist bronchodilators for non-acute asthma. Cochrane Database Syst Rev, (2002), pp. CD002158.
29. D.P. Tashkin, G.L. Klein, S.S. Colman, H. Zayed, W.H. Schonfeld. Comparing COPD treatment: nebulized, metered dose, inhaler, and concomitant therapy. Am J Med, 120 (2007), pp. 435-441, http://dx.doi.org/10.1016/j.amjmed.2006.07.043 
30. A.S. Melani, M. Bonavia, V. Cilenti, C. Cinti, M. Lodi, P. Martucci, et al. Inhaler mishandling remains common in real life and is associated with reduced disease control.
31. Respir Med, 105 (2011), pp. 930-938, http://dx.doi.org/10.1016/j.rmed.2011.01.005 
32. B.L. Laube, H.M. Janssens, F.H.C. de Jongh, S.G. Devadason, R. Dhand, P. Diot, et al. What the pulmonary specialist should know about the new inhalation therapies. Eur Respir J, 37 (2011), pp. 1308-1331, http://dx.doi.org/10.1183/09031936.00166410 
33.  J. Vestbo, S.S. Hurd, A.G. Agusti, P.W. Jones, C. Vogelmeier, A. Anzueto, et al. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med, 187 (2013), pp. 347-365, http://dx.doi.org/10.1164/rccm.201204-0596PP 
34. R. Dhand, M. Dolovich, B. Chipps, T.R. Myers, R. Restrepo, J.R. Farrar. The role of nebulized therapy in the management of COPD: evidence and recommendations. COPD, 9 (2012), pp. 58-72. http://dx.doi.org/10.3109/15412555.2011.630047.
35. Global initiative for asthma. Global strategy for asthma management and prevention. Available from: http://www.ginasthma.com [updated 2007; accessed 10.01.14].
36. Executive Committee GEMA 2009. Spanish guideline on the management of asthma. J Investig Allergol Clin Immunol, 20 (2010), pp. 1-59.
37. N. Gross, D. Tashkin, R. Miller, J. Oren, W. Coleman, S. Linberg. Inhalation by nebulization of albuterol–ipratropium combination (Dey combination) is superior to either agent alone in the treatment of chronic obstructive pulmonary disease. Dey Combination Solution Study Group. Respiration, 65 (1998), pp. 354-362.
38. D.P. Thaskin, G.L. Klein, S.S. Colman, H. Zayed, W.H. Schonfeld. Comparing COPD treatment: nebulized, metered dose inhaler, and concomitant therapy. Am J Med, 120 (2007), pp. 435-441. http://dx.doi.org/10.1016/j.amjmed.2006.07.043.