Albert Science International Organization

ARTICLE DESCRIPTION: 

Santanu Halder, Moumita Das Kirtania, Sanjay Dey, Rajkumar Ghosh, Sajal Kumar Jha, Anwesha Barik, Fabrication and Evaluation of Mikania micrantha extract loaded Transdermal Patch, ASIO Journal of Drug Delivery, 2022, 6(1): 09-13.

Department of Pharmaceutical Technology, School of Medical Sciences, Adamas University, Barasat - Barrackpore Road, 24-Parganas North, Jagannathpur, West Bengal 700126, India.

ARTICLE TYPE: RESEARCH

DOI Link:: http://doi-ds.org/doilink/10.2016-21915953/ ;

DOI Link :: https://doi-ds.org/doilink/07.2022-62173911/ASIO-JDD/10.2016-21915953/2022/V6/I1/921
ABSTRACT:

Being approved in the year 1981by USFDA, scopolamine loaded transdermal patch (Transderm-Scop), developed by ALZA Corp, USA was the first one to hit the market of transdermal drug delivery systems. Several other drugs including antihypertensives, anti-anginal, menopausal, anti-motion sickness has established its numerous advantages when delivered from commercially available transdermal drug delivery modules including some others which are currently under clinical investigations at different phases. Delivery of therapeutic/ diagnostic molecules via transdermal route not only maximizes flux in to systemic circulation at a reproducible rate but also reduce the risk of pre-systemic metabolism while minimizing the retention of drug in to the dosage form. Literature review suggests the antidiabetic as well as wound healing potential of the plant Mikania micrantha especially at the crude extract obtained from the dried leaves which urged us to design the experiment to fabricate drug loaded transdermal patches. These medicinal properties conferred by the aerial parts possibly owe to the presence of beta-caryophyllene in the essential oil due to its unique mechanism to bind to the cannabinoid 2 (CB2) receptors. The patches were found to maintain uniformity in weight which depicts the reproducibility in the formulation procedure while all other evaluation parameters such as surface pH, moisture content, folding endurance were found to be optimum. Overall the formulation turned out to be physically stable, without being dry and brittle.

Keywords: Transdermal Patch, M. micrantha, Antibacterial, wound healing, Crude extract.

[1] Bakir M, Facey PC, Hassan I, Mulder WH, Porter RB. Mikanolide from Jamaican Mikania micrantha. Acta crystallographica Section C, Crystal structure communications. 2004;60:o798-800.
[2] Ishak AH, Shafie N, Me N, Bahari H. Nutritional, Phytochemical and Pharmacological Properties of Mikania micrantha Kunth. Pertanika Journal of Scholarly Research Reviews. 2016;2:123-32.
[3] Rufatto L, Gower A, Schwambach J, Moura S. Genus Mikania: Chemical composition and phytotherapeutical activity. Revista Brasileira de Farmacognosia. 2012;22:1384-403.
[4] Ma H, Chen Y, Chen J, Ji J, He H. Identification and comparison of allelopathic effects from leaf and flower volatiles of the invasive plants Mikania micrantha. Chemoecology. 2021;31:355-65.
[5] Dev UK, Hossain TM, Islam Z. Phytochemical investigation, antioxidant activity and antihelmintic activity of  Mikania micrantha leaves. World Journal of Pharmaceutical Research. 2015; 4(5): 121-33.
[6] Lee SH, Kim DW, Eom SA, Jun SY, Park M, Kim DS, et al. Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein. BMB reports. 2012;45:354-9.
[7] Mc P-A, Ocotero V, Balcazar R, Jiménez F. Phytochemical and pharmacological studies on Mikania micrantha H.B.K. (Asteraceae). Phyton. 2010;79:77-80.
[8] Dougnon G, Ito M. Essential Oil from the Leaves of Chromolaena odorata, and Sesquiterpene Caryophyllene Oxide Induce Sedative Activity in Mice. Pharmaceuticals. 2021;14:651.
[9] Zhang M, Ling B, Kong C-H, Pang X, Liang G. Chemical components of volatile oil from Mikania micrantha and its biological activity on insects. Ying yong sheng tai xue bao = The journal of applied ecology / Zhongguo sheng tai xue xue hui, Zhongguo ke xue yuan Shenyang ying yong sheng tai yan jiu suo zhu ban. 2003;14:93-6.
[10] V E, León A, Chávez M, Torres Y, Apan M, Toscano R, et al. Sesquiterpene lactones from Mikania micrantha and M. cordifolia and their cytotoxic and anti-inflammatory evaluation. Fitoterapia. 2014;94: 155-63.
[11] Juliani HR. Physical and Chemical properties, Composition, and Biological Activity of Essential Oils of Philippine Medicinal Plants. Journal of Medicinally Active Plants. 2017; 5(2):28-35.
[12] Vasil'ev A, Krasnyuk I, Ravikumar S, Tokhmakhchi V. Transdermal Therapeutic Systems for Controlled Drug Release (A Review). Pharmaceutical Chemistry Journal. 2001;35:613-26.
[13] Murthy SN, Hiremath SR. Physical and chemical permeation enhancers in transdermal delivery of terbutaline sulphate. AAPS PharmSciTech. 2001;2(1):1-5.
[14] Development of a profitable procedure for the extraction of 2-H-1-benzopyran-2-one (coumarin) from Mikania glomerata. Drug Development and Industrial Pharmacy. 2001;27:103-6.
[15] Patel R, Patel G, Patel H, Baria A. Formulation and evaluation of transdermal patch of Aceclofenac. Research Journal of Pharmaceutical Dosage Forms and Technology. 2009;1(2):108-115.
[16] Prabhu P, Koland M, Kunhikatta V, Nairy H, G S, Ahmed MG. Preparation and evaluation of Transdermal patches of Papaverine hydrochloride. International Journal of Research in Pharmaceutical Sciences. 2010;1(3):259-266.
[17] Singh A, Bali A. Formulation and characterization of transdermal patches for controlled delivery of duloxetine hydrochloride. Journal of Analytical Science and Technology. 2016;7:25.