Albert Science International Organization

ARTICLE DESCRIPTION: 

Anamika Saxena, Santosh Kitawat. Formulation, Development and Evaluation of Microspheres of Ketoprofen by Using Different Polymers, ASIO Journal of Pharmaceutical & Herbal Medicines Research, 2015, 1(1): 41-47.

ARTICLE TYPE: RESEARCH

doi/dids No.: 12.2015-77737978

dids link: http://dids.info/didslink/12.2015-51846762/

ABSTRACT:

Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers having a particle size ranging from 1-1000 µm. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres as carriers for drugs also known as microparticles. Objective behind the preparation of microspheres were to increase the residence time in stomach with lesser direct contact with gastric mucosa. Formulations were prepared by emulsion-solvent evaporation method using a mixture of HPMC and Ethyl Cellulose was dissolved in 50ml of acetone to form a homogenous polymers solution. The prepared ketoprofen microspheres were discrete and free flowing and indicated that the concentration of polymer, stirring rate significantly influenced the formation of microspheres and ketoprofen entrapment while concentration of the polymer have a significant positive impact on ketoprofen release over a period of 12 hours and the stirring rate have minimal effect on the drug release. Microspheres revealed the absence of drug-polymer interactions. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature.

Key words: Microspheres, Ketoprofen, ethyl cellulose, HPMC, and solvent evaporation.

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