An International Publications House

Albert Science International Organization

Connecting People With Pioneering Thought

Albert Science International Organization (ASIO) is international , peer-reviewed , open access , cum print version & online journals.
Articles
Current
Archive
Special
Editorial Board
Paper In Publication Desk
Author Instruction
Author Desk
Call for Paper
Upcoming Journals and Books
Indexing of ASIO Journals
Author Instructions for Manuscript
Model Manuscript
Covering Letter
Publication Charges
Our Journals
ASIO Journal of Engineering & Technological Perspective Research (ASIO-JETPR) [ISSN: 2455-3794]
ASIO Journal of Medical & Health Sciences Research (ASIO-JMHSR)
ASIO Journal of Nursing & Physiotherapeutic Research (ASIO-JNPR)
ASIO Journal of Pharmaceutical & Herbal Medicines Research (ASIO-JPHMR) [ISSN: 2455-281X]
ASIO Journal of Microbiology, Food Science & Biotechnological Innovations (ASIO-JMFSBI) [ISSN: 2455-3751]
ASIO Journal of Chemistry, Physics, Mathematics & Applied Sciences (ASIO-JCPMAS) [ISSN: 2455-7064 ]
ASIO Journal of Humanities, Management & Social Sciences Invention (ASIO-JHMSSI) [ISSN: 2455-2224]
ASIO Journal of Analytical Chemistry (ASIO-JAC) [ISSN: 2455-7072]
ASIO Journal of Drug Delivery (ASIO-JDD) [ISSN: 2455-2828]
ASIO Journal of Experimental Pharmacology & Clinical Research (ASIO-JEPCR) [ISSN: 2455-7080]
ASIO Publication of Thesis & Dissertation (ASIO-PTD)
Health & Medicine Blog (ASIO)
JOURNALS || ASIO Journal of Pharmaceutical & Herbal Medicines Research (ASIO-JPHMR) [ISSN: 2455-281X]
AN OVERVIEW OF BUCCAL MUCOSA AS A SITE FOR DRUG DELIVERY

Author Names : Manju KC
Page No. : 12-16
Read Hit : 783
Pdf Downloads Hit : 37  volume 2 Issue 2
Article Overview

Abstract:

The oral mucosae in general are leaky epithelia intermediate between that of the epidermis and intestinal mucosa. It is estimated that the permeability of the buccal mucosa is 4-4000 times greater than that of the skin. The buccal mucosa offers several advantages for controlled drug delivery for extended periods of time. The mucosa is well supplied with both vascular and lymphatic drainage and first-pass metabolism in the liver and pre-systemic elimination in the gastrointestinal tract are avoided. The area is well suited for a retentive device and appears to be acceptable to the patient. With the right dosage form design and formulation, the permeability and the local environment of the mucosa can be controlled and manipulated in order to accommodate drug permeation. Buccal drug delivery is a promising area for continued research with the aim of systemic delivery of orally inefficient drugs as well as a feasible and attractive alternative for non-invasive delivery of potent peptide and protein drug molecules. However, the need for safe and effective buccal permeation/absorption enhancers is a crucial component for a prospective future in the area of buccal drug delivery. More over buccal drug absorption can be terminated promptly in case of toxicity by removing the dosage form from the buccal cavity. It is also possible to administer the drug to patients who cannot be dosed orally to prevent accidental swallowing.

Keywords: Pre-systemic elimination, non-invasive delivery, permeability.

Reference
  1. Dr. Pande SD, Vaidya KPV and Gulhane KPN (2013) Floating Drug Delivery System (FDDS): A new way for oral drug delivery system. International Journal of Pharmaceutical and Clinical Science 3, 1-13.
  2. Mrsny RJ (2013) Perspective: Oral Drug Delivery Research in Europe. Journal of Controlled Release 161, 247-253.
  3. Kohli K, Chopra S, Arora S, Khar K and Dhar D (2010) Self Emulsifying Drug Delivery Systems: An Approach to Enhance Oral Bioavailability. Drug discovery today 15, 958-966.
  4. Arunachalam A, Asutoskumar S, Kartikeyan M, Konam K, Pottabathulaa HP and Sethuraman S (2010) Solid Dispersions: A Review. Current Pharma Research 1, 1-9.
  5. Khirwadkar P and Dashora K (2011) Gasstroretentive Dosage Forms: Current Development in Novel System Design and Evaluation. American journal of pharmaTech Research 1, 58-89.
  6. Streubel A, siepmann J and Bodmeier R (2006) Gastro Retentive Drug Delivery Systems. Expert Opinion on Drug Delivery. 3, 217-233.
  7. Pawar VK, Kasnal S , Garg G, Awasthi R, Kulkarni GT and Singodia D (2011) Gastro retentive Dosage Forms: A Review with Special Emphasis on Floating Drug Delivery Systems. Drug Delivery 18, 97-110.
  8. Kaur P, Dhimans and Arora S (2013) Floating Bilayer Tablet Technology: A Review. Int. J. Pharm. Sci. Rev. Res. 19,112-122.
  9. Zate SU, Kothawade PI, Mahale GH, Kapse KP and Anantwar SP (2010) Gastro Retentive Bioadhesive Drug Delivery System: A Review. International Journal of PharmTech Research 2, 1227-1235.
  10. Vinod KR, Gangadhar MS, Sandhya S and David V (2013) Critical Assesment Pertaining to Gastric Floating Drug Delivery Systems. Journals for Drug and Medicine, 5, 41-58.
  11. Talukder and Fassihi R (2004) Gastro Retentive Delivery systems: A Mini Review. Drug Development and Industrial Pharmacy 30, 1019-1028.
  12. Nayak AM, Maji R and Das B (2010) Gastro retentive Drug Delivery Systems: A Review.  Asian Journal of Pharmaceutical and Clinical Research 3, 1-9.
  13. Dhirendra K, lewis , Udupa N and Atin K (2009) Solid Dispersions : A Review.  Pak. J. pharm. Sci. 22, 234-246.
  14. Patidar K, Kshirsagar MD, Soni M and Saini V (2011) Solid Dispersion Technology: A Boom for Poor Water Soluble Drugs. Indian Journal of Novel Drug Delivery 3, 83-90.
  15. Srinarong P, Waard HD, Frijlink HW and Hinrichs WL (2011) improved dissolution behavior of lipophilic drugs by solid dispersions: the production process as starting point for formulation considerations. Expert opin. Drug deliv 8, 1121-1140.
  16. Wätzig H (2008) Validation of analytical methods using Capillary Electrophoresis. Separation Science and Technology: Academic Press.  225-244.
  17. Rambla-Alegre M, Esteve-Romero J, Carda-Broch S (2012) Is it really necessary to validate an analytical method or not? That is the question. Journal of Chromatography 1232, 101-109.
  18. Yuwono M, Indrayanto G (2005) Validation of Chromatographic Methods of Analysis. Profiles of Drug Substances, Excipients and Related Methodology: Academic Press. 243-259.
  19. Lacroix PM (2005) Pharmaceutical Analysis and Drug Purity Determination  In Paul W, Alan T, Colin P, Encyclopedia of Analytical Science (Second Edition edition) Oxford: Elsevier. 89-95.
  20. Clough SR (2005) Cefpodoxime In Editor-in-Chief: Philip W, Encyclopedia of Toxicology (Second Edition) New York: Elsevier. 332-334.
  21. Alothman ZA, Bukhari N, Haider S, Wabaidur SM, Alwarthan AA (2010) Spectrofluorimetric determination of Ranitidine Hydrochloride in pharmaceutical preparation. Arabian Journal of Chemistry 3, 251-255.
  22. Nayon MA, Uddin AN, Burshra U, Amran AS and Nesa J (2013) Development and Validation of Spectrophotometric method for the determination of Cefixime Trihydrate in bulk and Pharmaceutical formulation. Asian journal of biomedical and pharmaceutical sciences 3, 1-5.
  23. Garcia PL, Buffoni E, Gomes FP and Quero JLV (2011) Analytical Method Development. Wide Spectra of Quality Control 6, 1-20.
  24. Moffat AC, Osselton MD, and Widdop B. (2004) Clarke’s Analysis of Drugs and Poisons in Pharmaceuticals, Body Fluids and Postmortem Material,. 4th ed. London, UK,: Pharmaceutical Press, 222-287.
  25. Arora SC, Sharma PK, Khatar A, Gagoria J, Singh N and Irchhaiya R (2010) Development, Characterization and Solubility Study of Cefpodoxime Proxetil by Solvent Evaporation Method. International Journal of ChemTech Research 2, 1156-1162.
  26. Fulton B and Perry CM (2001) Cefpodoxime Proxetil. Pediatric drugs 3, 137-158
  27. Castle SS (2007) Cefpodoxime. Elsevier Inc 1, 1-5.
  28. Ogawa R and Echizen H (2011) Clinicallly Significant Drug Interactions with Antacids. Adis data Information 17, 1839-1864.
  29. Amidon G, Lennernas H, Shah V, Crison J (1995) A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability Pharmaceutical Research 12, 413-420.
  30. Lindenberg M, Kopp S, Dressman JB (2004) Classification of orally administered drugs on the World Health Organization Model list of Essential Medicines according to the biopharmaceutics classification system European Journal of Pharmaceutics and Biopharmaceutics 58, 265-278.
  31. Alam MA, Ali R, Al-Jenoobi FI, Al-Mohizea AM (2012) Solid Dispersions: A Strategy for Poorly Aqueous Soluble Drugs and Technology Updates. Expert Opinion on Drug Delivery 9, 1419-1440.
  32. Alsaidan SM, Alsughayer AA, Eshra AG (1998) Improved Dissolution Rate of Indomethacin by Adsorbents Drug Development and Industrial Pharmacy 24(4), 389-394.
  33. Monkhouse DC, Lach JL (1972) Use of Adsorbents in Enhancement of Drug Dissolution. Journal of Pharmaceutical Sciences 61, 1430-1435.
  34. Reddy BBK and Karunakar A (2011) Biopharmaceutics classification System: An Regulatory Approach.  Dissolution Technology 18, 31-38.
  35. Konno T (1990) Physical and Chemical Changes of Medicinals in Mixtures with Adsorbents in the Solid State. IV. : Study on Reduced-Pressure Mixing for Practical Use of Amorphous Mixtures of Flufenamic Acid Chemical & pharmaceutical bulletin 38, 2003-2007.
  36. Zhao N, Augsburger LL (2006) The Influence of Granulation on Super Disintegrant Performance Pharmaceutical Development and Technology 11, 47-53.
  37. Sahoo J, Murthy PN, Biswal S Avari JG and Girdkar RP (2008) Enhancement of Dissolution of Gliclazide Using Solid Dispersions with Polyethylene glycol 6000. APPS Pharm Sci Tech 9, 563-571.
  38. Patel T, Patel LD and Makwana S (2010) Enhancement of Dissolution of Fenofibrate by Solid Dispersion Technique. Int. J. Res. Pharm.Sci. 1, 127-132.
  39. Shim JB, Kim MJ, Kim SJ and Kang SJ (2012) Dissolution Properties of Controlled Released Solid Dispersion of Carvidol with HPMC and Eudragit RS. Journal of pharmaceutical investigation 4, 285-291.
  40. Baumgartner S, Kristl JVR, and Zorko B (2009) Optimization of Floating Matrix Tablets and Evaluation of Their Gastric Residence Time. International Journal of Pharmaceutics, 195, 125-135.