Manish M. Wanjari, Vanika Bajpai, Yadu Nandan Dey, Sudesh N. Gaidhani, Gajji Babu, Chenopodium Album Linn. Leaves prevent carbon tetrachloride-induced liver fibrosis in rats, ASIO Journal of Experimental Pharmacology & Clinical Research (ASIO-JEPCR), 2016, 1(1): 16-22.
ARTICLE TYPE: RESEARCH
dids no.: 03.2016-35559215,
dids Link: http://dids.info/didslink/03.2016-25637255/
The leaves of Chenopodium album Linn. are traditionally used in treatment of jaundice and spleen enlargement. The present work investigated the effect of aqueous extract of leaves of Chenopodium album on experimentally induced hepatotoxicity in rats to substantiate the traditional use in liver diseases. The hepatotoxicity was induced in rats by carbon tetrachloride (CCl4) treatment and in addition, vehicle or aqueous extract of the leaves of Chenopodium album (CAE) (100, 200 and 400 mg/kg) or silymarin (25 mg/kg) were administered daily orally for seven days. The hepatotoxicity was assessed by estimating the activities of marker enzymes and by histological studies. The oxidative stress was assessed by measuring lipid peroxidation and activities of superoxide dismutase and catalase in liver. The CAE treatment significantly prevented the CCl4-induced elevations the serum levels of glutmate oxaloacatate transaminase, pyruvate oxaloacatate transaminase, alkaline phosphatase, bilirubin, lactate dehydrogenase and triglycerides while decreased the total protein. Treatment with CAE attenuated the CCl4-induced fibrosis in liver tissue and also decreased elevated lipid peroxidation levels and inhibited decrease in activities of superoxide dismutase and catalase enzymes in liver. The effects of the CAE were comparable to that of standard antioxidant hepatoprotective agent, silymarin. These findings indicate the CAE exhibited hepatoprotective effect against CCl4-induced liver fibrosis which may be attributed to antioxidant action of CAE due to presence of antioxidant phytochemicals like flavonoids and other phenolic compounds. It indicates the therapeutic potential of Chenopodium album leaves and validates its traditional medicinal use in liver disorders.
Keywords: Bathua; Hepatotoxicity; Silymarin; Oxidative stress, Masson’s trichrome
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