Bratati Bandyopadhyay, Prof. Biswanath Ghosh. Study of Anti-Inflammatory Activity of Whole Plant Extract of Parthenium Hysterophorus Linn, ASIO Journal of Pharmaceutical & Herbal Medicines Research (ASIO-JPHMR), 2016: 2(1), 24-27.
ARTICLE TYPE: Research
dids/doi No.: 12.2015-77737978
dids link: http://dids.info/didslink/02.2016-63857117/
Inflammation is a non specific, localized immune reaction of the organism, which tries to localize the pathogen agent. Parthenium hysterophorus L., belongs to the dicot family of flowering plants (ASTERACEAE). Parthenium hysterophorus Linn is also known as carrot grass, congress grass, chatak chandini. This plant traditionally used for the treatment of fevers, migraine headaches, rheumatoid arthritis, stomachaches, toothaches, insect bites, infertility, and problems with menstruation and labor during childbirth. The plant contains a large number of important bioactive compounds, mainly sesquiterpene lactones, flavonoid glycosides and pinenes. It has multiple pharmacologic properties, such as anticancer, anti-inflammatory, cardiotonic, antispasmodic, an emmenagogue, and as an enema for worms etc. Whole plant parts of Parthenium hysterophorus L. was collected and extracted the dried powder with the help of methanol by using Soxhlet extractor. The phytochemical investigations were carried out by using various earlier reported methods. Carageenan was administered on nine Wiester rat and then the activity at the site (paw) got induced and inflammation was created. After performing the experiment it was concluded that both the activity of test and the standard drug were significant than that of control. So it was concluded that the test drug (which was the methanolic extract of whole plants of Parthenium hysterophorus) has shown a significant anti inflammatory activity.
Key Words: Inflammation, Parthenium hysterophorus, Carageenan, Wiester rat, anti inflammatory activity
- Pandey K, Sharma P K, Dudhe R. Antioxidant and anti inflammatory activity of ethanolic extract of Parthenium hysterophorus linn., Asian Journal of Pharmaceutical and Clinical Research, 2012, 5 (4):28-31.
- Jain NK and Kulkarni SK. Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats, Journal of Ethnopharmacology, 1999, 68:251–259.
- Pareek A, Suthar M, Rathore GS, Bansal V. Feverfew (Tanacetum parthenium L.): A systematic review, Pharmacognosy Reviews, 2011, 5:103–110.
- Berry MI. Feverfew faces the future, Pharmaceutical Journal, 1984, 232: 611–614.
- Datta S and Saxena DB. Pesticidal properties of parthenin (from Parthenium hysterophorus) and related compounds, Pest Management Science, 2001, 57: 95–101.
- Narasimhan TR, Ananth M, Swamy MN, Babu MR, Mangala A, Rao PV. Toxicity of Parthenium hysterophorus L. to cattle and buffaloes, Experientia 1977, 33: 1358–1359.