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JOURNALS || ASIO Journal of Experimental Pharmacology & Clinical Research (ASIO-JEPCR) [ISSN: 2455-7080]
SCIENTIFIC VALIDATION OF ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACTS OF TECOMA STANS (L) JUSS. LEAF
Author Names : Deepak Kumar Page No. : 01-13
Read Hit : 47
Pdf Downloads Hit : 1 Volume 9 Issue 1
ARTICLE DESCRIPTION:
Doi: 10.2016-37245516/; Link :: https://doi-ds.org/doilink/01.2026-42348266/ASIO-JEPCR:2026/V9/I1/1042/DK
Deepak Kumar1†, Raman Shivhare1, Sunil Singh1, Yogendra Singh1, Vishnu Kant2
1Shri Ramnath Singh Mahavidhyalaya (Pharmacy), Gormi, Bhind (M.P.)
2 Azad College of Education (Pharmacy), Shakha Janwara, Kanpur (U.P.)
Abstract:
Diabetes mellitus (DM) currently is a major health problem of the world and due to chronic metabolic syndrome resulting from a variable interaction of hereditary and environmental factors and is characterized by abnormal insulin secretion or insulin receptor or post-receptor events, affecting metabolism involving carbohydrates, proteins and fats in addition to damaging liver, kidney and beta-cell of pancreas. The Tecoma Stans(L) juss is not scientifically validated and which was traditionally practicing herb. The work provides scientific validation for use of leaf against diabetes mellitus. The current study is help to develop a plant based diabetic drug which will be evaluated by using in-vivo streptozocin induced diabetes in rats. The leaves of plant, dried under shade are carefully removed and grinded using a blender. The coarse power so obtained was used for the extraction by successive solvent extraction by Soxhlet apparatus using various solvents. The extract with maximum number of phyto-constituents and extractive value identified (ethanolic) is used in the further evaluations. Toxicity study shows the safety nature of the extract and also acute and sub-acute toxicity study does not produce any toxic symptoms upto 500 mg/kg. The extract was pre-clinically evaluated against STZ induced diabetic rats models for its antidiabetic activity. The extract showed insulin mimetic activity and control of blood sugar level which are comparable to the reference drug glibenclamide at a dose of 10mg/kg. As the in-vivo results indication has been concluded 50% ethanolic extract of Techoma Stanus (L), which may be containing structurally insulin resembled compounds. In conclusion the extract is safe and can be used to treat diabetic condition without any harmful effects.
Keywords: Diabetes mellitus, Tecoma Stans (L), 50% ethanolic extract, leaf, streptozocin, antidiabetic activity.
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